TRPV4 and KRIT1

Data Source:
BioGRID (unspecified method)

		TRPV4	KRIT1
Description		transient receptor potential cation channel subfamily V member 4	KRIT1 ankyrin repeat containing
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GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Cilium Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction
	Molecular Function	Actin Binding Protein Kinase C Binding Ion Channel Activity Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Cellular Response To Heat Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Microtubule Polymerization Multicellular Organismal Water Homeostasis Cartilage Development Involved In Endochondral Bone Morphogenesis Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		TRP channels
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC) Distal hereditary motor neuropathies (dHMN)	Cerebral cavernous malformation
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010)	Coffee consumption ( 31046077) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	7 interacting genes: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4 UBE2K
Entrez ID		59341	889
HPRD ID		05667	05020
Ensembl ID		ENSG00000111199	ENSG00000001631
Uniprot IDs		Q9HBA0	A4D1F7 O00522
PDB IDs		4DX1 4DX2	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4
Enriched GO Terms of Interacting Partners?
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