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TRPV4 and PACSIN3
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
TRPV4
PACSIN3
Description
transient receptor potential cation channel subfamily V member 4
protein kinase C and casein kinase substrate in neurons 3
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Cytoplasmic Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Focal Adhesion
Cilium
Integral Component Of Membrane
Apical Plasma Membrane
Lamellipodium
Filopodium
Growth Cone
Cortical Actin Cytoskeleton
Ruffle Membrane
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Plasma Membrane
Extracellular Exosome
Molecular Function
Actin Binding
Protein Kinase C Binding
Ion Channel Activity
Cation Channel Activity
Calcium Channel Activity
Protein Binding
Calmodulin Binding
ATP Binding
Microtubule Binding
Lipid Binding
Stretch-activated, Cation-selective, Calcium Channel Activity
Protein Kinase Binding
SH2 Domain Binding
Identical Protein Binding
Alpha-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Actin Filament Binding
Protein Binding
Phospholipid Binding
Cytoskeletal Protein Binding
Lipid Binding
Calcium Channel Inhibitor Activity
Identical Protein Binding
Biological Process
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Cell Volume Homeostasis
Actin Filament Organization
Cell-cell Junction Assembly
Positive Regulation Of Cytosolic Calcium Ion Concentration
Osmosensory Signaling Pathway
Response To Mechanical Stimulus
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Microtubule Depolymerization
Actin Cytoskeleton Reorganization
Cellular Response To Heat
Positive Regulation Of Vascular Permeability
Cortical Microtubule Organization
Microtubule Polymerization
Multicellular Organismal Water Homeostasis
Cartilage Development Involved In Endochondral Bone Morphogenesis
Calcium Ion Import
Calcium Ion Transmembrane Transport
Cellular Response To Osmotic Stress
Cellular Hypotonic Response
Blood Vessel Endothelial Cell Delamination
Calcium Ion Import Across Plasma Membrane
Calcium Ion Import Into Cytosol
Endocytosis
Cytoskeleton Organization
Regulation Of Endocytosis
Negative Regulation Of Endocytosis
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Negative Regulation Of Calcium Ion Transport
Plasma Membrane Tubulation
Pathways
TRP channels
Clathrin-mediated endocytosis
Drugs
Cannabidiol
Butamben
Medical Cannabis
Nabiximols
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia
TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
Distal hereditary motor neuropathies (dHMN)
GWAS
Creatinine levels (
29403010
)
Glomerular filtration rate (
29403010
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Waist-to-hip ratio adjusted for body mass index (
26785701
)
Interacting Genes
14 interacting genes:
CALM1
FYN
HCK
ITCH
KRIT1
LCK
LYN
MAP7
OS9
PACSIN1
PACSIN2
PACSIN3
SRC
YES1
23 interacting genes:
ADAM12
ADAM15
ASAP1
ASAP2
ATXN7L2
CLNK
DNM1
ITSN1
KRTAP12-2
LGALS13
PACSIN1
PACSIN2
PAK2
RAF1
SMARCD1
SOS1
SOS2
SPRY2
SYNJ1
TERF2IP
TNPO2
TRPV4
WASL
Entrez ID
59341
29763
HPRD ID
05667
05937
Ensembl ID
ENSG00000111199
ENSG00000165912
Uniprot IDs
Q9HBA0
Q9UKS6
PDB IDs
4DX1
4DX2
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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