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YES1 and DVL2
Data Source:
BioGRID
(two hybrid)
YES1
DVL2
Description
YES proto-oncogene 1, Src family tyrosine kinase
dishevelled segment polarity protein 2
Image
GO Annotations
Cellular Component
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Ion Channel Binding
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Biological Process
Cellular Protein Modification Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
T Cell Costimulation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Innate Immune Response
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Pathways
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Dasatinib
Fostamatinib
Diseases
GWAS
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
30224653
29403010
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Interacting Genes
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GAS8
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
PXN
RASA1
RPL10
SH3GLB2
SKAP2
SLC9A3R1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
Entrez ID
7525
1856
HPRD ID
01285
03690
Ensembl ID
ENSG00000176105
ENSG00000004975
Uniprot IDs
P07947
O14641
PDB IDs
2HDA
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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