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RAD17 and USP20
Data Source:
BioGRID
(enzymatic study)
RAD17
USP20
Description
RAD17 checkpoint clamp loader component
ubiquitin specific peptidase 20
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Rad17 RFC-like Complex
Cytoplasm
Centrosome
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
Chromatin Binding
DNA Clamp Loader Activity
Protein Binding
ATP Binding
G Protein-coupled Receptor Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Zinc Ion Binding
Biological Process
DNA Replication Checkpoint
DNA Damage Checkpoint
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Negative Regulation Of DNA Replication
Intra-S DNA Damage Checkpoint
Mitotic DNA Replication Checkpoint
Regulation Of Phosphorylation
Regulation Of Signal Transduction By P53 Class Mediator
Ubiquitin-dependent Protein Catabolic Process
Endocytosis
Regulation Of G Protein-coupled Receptor Signaling Pathway
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ub-specific processing proteases
Drugs
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Metabolite levels (
23823483
)
Interacting Genes
15 interacting genes:
ATM
ATR
HUS1
MCM7
POLE
PRKDC
PRMT6
RAD1
RAD9A
RAD9B
RFC2
RFC3
RFC4
SNU13
USP20
69 interacting genes:
AGR2
ALAS1
APBA2
ARID5A
ASCL1
ATP6V1G2
BEND5
BEND7
BHLHB9
BRPF1
C1QTNF2
CCNL2
CDK2AP1
CLSPN
CTAG1A
CTAG1B
DIO2
ENKD1
EPAS1
FATE1
FTO
GPRASP2
GTF2IRD1
HAND2
HIF1A
HSF2BP
IHO1
IRAK1BP1
ITGB3BP
KLHL20
LMNA
MAGEA11
MAPK6
MBD3L1
MCCD1
MDFI
MEOX2
MRPL28
PBX4
PJA1
PLA2G2A
PRKACA
PRKCI
RAD17
RSPO4
SAMD12
SPRY2
SRGAP2B
STING1
TNNI1
TRIB3
TRIM23
TTC19
TTC23L
ULK1
USP15
USP21
USP28
VAPA
VAPB
VAX1
VHL
WASHC1
ZBTB10
ZFYVE26
ZNF343
ZNF408
ZNF620
ZXDB
Entrez ID
5884
10868
HPRD ID
09124
07505
Ensembl ID
ENSG00000152942
ENSG00000136878
Uniprot IDs
O75943
Q9Y2K6
PDB IDs
6KCZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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