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RAD17 and POLE
Data Source:
HPRD
(in vivo, in vitro)
RAD17
POLE
Description
RAD17 checkpoint clamp loader component
DNA polymerase epsilon, catalytic subunit
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Rad17 RFC-like Complex
Nucleus
Nucleoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Molecular Function
Chromatin Binding
DNA Clamp Loader Activity
Protein Binding
ATP Binding
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity
4 Iron, 4 Sulfur Cluster Binding
Biological Process
DNA Replication Checkpoint
DNA Damage Checkpoint
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Negative Regulation Of DNA Replication
Intra-S DNA Damage Checkpoint
Mitotic DNA Replication Checkpoint
Regulation Of Phosphorylation
Regulation Of Signal Transduction By P53 Class Mediator
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication Initiation
Leading Strand Elongation
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
DNA Replication Proofreading
Embryonic Organ Development
Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Drugs
Cladribine
Diseases
GWAS
Blood urea nitrogen levels (
31152163
)
Body mass index (
26426971
)
Metabolite levels (
23823483
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
15 interacting genes:
ATM
ATR
HUS1
MCM7
POLE
PRKDC
PRMT6
RAD1
RAD9A
RAD9B
RFC2
RFC3
RFC4
SNU13
USP20
12 interacting genes:
ABHD16A
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE4
RAD17
STK19
TOPBP1
XRCC5
Entrez ID
5884
5426
HPRD ID
09124
07177
Ensembl ID
ENSG00000152942
ENSG00000177084
Uniprot IDs
O75943
Q07864
PDB IDs
5VBN
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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