RAB27B and UNC13D

Data Source:
HPRD (in vitro)

		RAB27B	UNC13D
Description		RAB27B, member RAS oncogene family	unc-13 homolog D
Image			No pdb structure
GO Annotations	Cellular Component	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm	Extracellular Region Lysosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Recycling Endosome Exocytic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Granuloma Formation Germinal Center Formation Phagocytosis Regulation Of Mast Cell Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Defense Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Eosinophil counts ( 27863252) Major depressive disorder ( 27777418) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White matter hyperintensity burden ( 25663218)
Interacting Genes		11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D	3 interacting genes: LMNA RAB27A RAB27B
Entrez ID		5874	201294
HPRD ID		04846	10598
Ensembl ID		ENSG00000041353	ENSG00000092929
Uniprot IDs		O00194	Q70J99
PDB IDs		2F7S
Enriched GO Terms of Interacting Partners?
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