UNC13D and RAB27B

Data Source:
HPRD (in vitro)

		UNC13D	RAB27B
Description		unc-13 homolog D	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Late Endosome Cytosol Membrane Weibel-Palade Body Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Recycling Endosome Exocytic Vesicle	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Granuloma Formation Germinal Center Formation Phagocytosis Regulation Of Mast Cell Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Defense Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Regulated Secretory Pathway	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Neutrophil degranulation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Eosinophil counts ( 27863252) Major depressive disorder ( 27777418) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418) White matter hyperintensity burden ( 25663218)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		3 interacting genes: LMNA RAB27A RAB27B	11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D
Entrez ID		201294	5874
HPRD ID		10598	04846
Ensembl ID		ENSG00000092929	ENSG00000041353
Uniprot IDs		Q70J99	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?
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