TRIM54 and CBX8

Data Source:
BioGRID (two hybrid)

		TRIM54	CBX8
Description		tripartite motif containing 54	chromobox 8
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GO Annotations	Cellular Component	Cytoplasm Microtubule Microtubule Associated Complex Z Disc	Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Single-stranded RNA Binding Protein Binding Methylated Histone Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organism Development Protein Ubiquitination Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Histone Ubiquitination Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Plateletcrit ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		317 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIFM2 AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf109 C1orf216 C1orf35 C1QTNF2 C2CD6 C2orf49 C8orf74 CALM3 CARD9 CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GAS8 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1	87 interacting genes: ABLIM3 BACH2 BANP BMI1 CALCOCO2 CARD10 CARD9 CCDC136 CCDC57 CEP70 DVL3 EEF1G FHL3 FSD2 FXR1 GIGYF1 GOLGA2 GOLGA6L9 GPRASP2 GRIPAP1 H3-4 HAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 JADE2 JAKMIP1 KANK2 KAT5 KAT7 KCTD9 KIFC3 KRT31 KRT34 KRT40 LSM2 LZTS2 MB21D2 MCC MDFI MID2 MLLT1 MLLT3 MTUS2 NAB2 PAXIP1 PCGF5 PHACTR1 PIBF1 PICK1 PIH1D2 PLEKHF2 PNMA1 PNMA2 POLR1C PRDM6 PRKAR1B RASSF3 RING1 RPGRIP1 SESTD1 SETDB1 SOX5 TAX1BP1 TEPSIN TFCP2 TFIP11 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC22D4 TSGA10 TTC23 UNC119 USH1G USP11 USP7 VIM ZBTB14 ZBTB8A ZBTB9 ZNF185 ZRANB1
Entrez ID		57159	57332
HPRD ID		05928	13006
Ensembl ID		ENSG00000138100	ENSG00000141570
Uniprot IDs		Q9BYV2	Q9HC52
PDB IDs		3Q1D	2N4Q 3I91 5EQ0
Enriched GO Terms of Interacting Partners?
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