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TRIM54 and UBE2I
Data Source:
BioGRID
(two hybrid)
TRIM54
UBE2I
Description
tripartite motif containing 54
ubiquitin conjugating enzyme E2 I
Image
GO Annotations
Cellular Component
Cytoplasm
Microtubule
Microtubule Associated Complex
Z Disc
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Transferase Complex
Sumoylated E2 Ligase Complex
Molecular Function
Protein Binding
Microtubule Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
SUMO Transferase Activity
Enzyme Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Biological Process
Microtubule-based Process
Negative Regulation Of Microtubule Depolymerization
Signal Transduction
Multicellular Organism Development
Protein Ubiquitination
Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Chromosome Segregation
Viral Process
Protein Sumoylation
Negative Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of SUMO Transferase Activity
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Interacting Genes
317 interacting genes:
AAMDC
ABHD17C
ADCY4
AGFG1
AIFM2
AK2
AK3
ANKRD11
ANKRD45
ARFIP2
ARHGAP29
ARHGEF5
ARHGEF6
ARMC7
ATXN3
ATXN3L
ATXN7
BBX
BMF
BSCL2
BYSL
C14orf39
C1orf109
C1orf216
C1orf35
C1QTNF2
C2CD6
C2orf49
C8orf74
CALM3
CARD9
CAVIN2
CBX8
CCDC102B
CCDC146
CCDC17
CCDC26
CCDC28A
CCDC87
CCHCR1
CCNC
CDC37
CDK18
CDKAL1
CDKN1A
CENPX
CEP57L1
CEP68
CFAP100
CFAP206
CFAP53
CHCHD2
CHD2
CHD3
CKM
CLPP
CMIP
CNGA3
CRADD
CSNK2B
CTNNA3
CWF19L2
CYTH4
DAXX
DCAF8
DCLRE1B
DCUN1D1
DDX6
DEUP1
DNAL4
DNASE1L1
DPYSL4
DRG2
DTNB
DTX2
DUSP16
DVL3
DYNC2I2
DYNLL1
EHHADH
EIF4E2
ELMO1
ELOA
ENKD1
EPHB2
EPM2AIP1
EXOC7
EXOC8
EXOSC5
EXTL2
FAM110A
FAM124A
FAM124B
FAM161A
FAM50B
FAM90A1
FAM9A
FARS2
FBF1
FBXO16
FBXW2
FLNC
FMNL1
G2E3
GAS8
GEM
GIMAP2
GLP2R
GMCL1
GNG13
GNL3L
GTF2I
GTF2IRD2
GTF2IRD2B
HAUS1
HBG1
HDAC10
HGS
HMMR
HOXB5
HSF2
HSPB1
HYAL2
IL18RAP
IL36A
IL4I1
ING3
INPP5J
IQUB
ITGAE
ITPKB
JOSD1
KANK2
KAT14
KDM1A
KIF9
KIFC3
KLHL38
KLHL42
KPNA2
KRT1
KRT3
KRT4
KRT6A
KRT6B
KRT6C
KRT75
KRT76
KRT78
KRT79
KRT8
KRTAP11-1
KRTAP9-2
LENG1
LIN37
LINC00887
LMO1
LMO2
LMO3
LMO4
LNX1
LSM2
MAD2L2
MAOB
MAPK3
MBD3
MCM7
MEAF6
MFAP1
MGARP
MICAL2
MID2
MNS1
MRTFA
MSH5
MYLK2
MYO15B
MYO5B
NEK6
NGLY1
NTAQ1
NUP54
NUP58
OFCC1
OSGIN1
OSTF1
OTUB1
OTUB2
PABPC3
PAIP2
PARVG
PCDHGB1
PCDHGC3
PCSK7
PDZK1IP1
PICK1
PIK3R3
PIWIL1
PLEKHM1
PLK4
PPIG
PPP1R18
PRF1
PRKAB2
PRKG1
PRMT5
PRPF18
PRR35
PSMA1
PYGM
RAB35
RABGEF1
RAD23A
RAPSN
RASSF10
RBM15B
RBM41
RCOR3
RELT
RIMS3
RNF4
RSRC2
RUNX1T1
SCNM1
SDCBP
SEC14L4
SELE
SEMA4C
SENP3
SH2D1B
SHC3
SLC13A2
SLITRK3
SMARCD1
SMARCE1
SNF8
SOX14
SPG21
SPRING1
SSX2IP
STAM
STRC
STXBP4
STYXL1
SYCE3
SYTL5
TBC1D22B
TCAF1
TCAP
TCEA2
TCEANC
TCHP
TEAD4
TEPSIN
THAP4
THOC1
TJAP1
TLE6
TLR10
TMEM30A
TNFAIP1
TNR
TRIM55
TRIM63
TRIM69
TRIML2
TSG101
TSHZ3
TSPEAR
TSSK3
TTC23
TTC9C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2N
UBE2U
UBE2V2
UBL4A
UCHL1
UCHL3
UCHL5
USHBP1
USP15
USP18
USP2
USP21
USP33
USP35
USP4
USP5
USP7
USP8
UTP14C
VAMP4
VCAM1
VCP
VPS28
VPS9D1
XAF1
YEATS4
YOD1
ZBTB16
ZFHX3
ZGPAT
ZNF180
ZNF182
ZNF250
ZNF267
ZNF366
ZNF417
ZNF572
ZNF587
ZNF667-AS1
471 interacting genes:
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARL13B
ARL6IP1
ARNT
ARNTL
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMI1
BTBD3
C18orf25
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBSL
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDKN1B
CDR2L
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4-16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFKBIA
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PDLIM7
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX6
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM3
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
Entrez ID
57159
7329
HPRD ID
05928
09045
Ensembl ID
ENSG00000138100
ENSG00000103275
Uniprot IDs
Q9BYV2
A8K503
B0QYN7
P63279
PDB IDs
3Q1D
1A3S
1KPS
1Z5Q
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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