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CBX8 and BMI1
Data Source:
HPRD
(two hybrid, in vitro)
CBX8
BMI1
Description
chromobox 8
BMI1 proto-oncogene, polycomb ring finger
Image
GO Annotations
Cellular Component
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Nuclear Body
PcG Protein Complex
PRC1 Complex
Molecular Function
Single-stranded RNA Binding
Protein Binding
Methylated Histone Binding
Ubiquitin-protein Transferase Activator Activity
Protein Binding
Zinc Ion Binding
RING-like Zinc Finger Domain Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Histone Ubiquitination
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of DNA Repair
Regulation Of Catalytic Activity
Cellular Response To Hydrogen Peroxide
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Silencing
Segment Specification
Regulation Of Gene Expression
Hemopoiesis
Histone H2A-K119 Monoubiquitination
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of G0 To G1 Transition
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
Drugs
Diseases
Penile cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Plateletcrit (
32888494
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Youthful appearance (self-reported) (
32339537
)
Prostate-specific antigen levels (
28139693
)
Interacting Genes
87 interacting genes:
ABLIM3
BACH2
BANP
BMI1
CALCOCO2
CARD10
CARD9
CCDC136
CCDC57
CEP70
DVL3
EEF1G
FHL3
FSD2
FXR1
GIGYF1
GOLGA2
GOLGA6L9
GPRASP2
GRIPAP1
H3-4
HAP1
HMBOX1
HOMEZ
HOOK2
HSF2BP
IKZF1
JADE2
JAKMIP1
KANK2
KAT5
KAT7
KCTD9
KIFC3
KRT31
KRT34
KRT40
LSM2
LZTS2
MB21D2
MCC
MDFI
MID2
MLLT1
MLLT3
MTUS2
NAB2
PAXIP1
PCGF5
PHACTR1
PIBF1
PICK1
PIH1D2
PLEKHF2
PNMA1
PNMA2
POLR1C
PRDM6
PRKAR1B
RASSF3
RING1
RPGRIP1
SESTD1
SETDB1
SOX5
TAX1BP1
TEPSIN
TFCP2
TFIP11
TRAF2
TRIB3
TRIM23
TRIM27
TRIM54
TSC22D4
TSGA10
TTC23
UNC119
USH1G
USP11
USP7
VIM
ZBTB14
ZBTB8A
ZBTB9
ZNF185
ZRANB1
42 interacting genes:
CASC9
CBX8
CEP126
CSNK2B
E2F6
FOXS1
H2AC18
H2AC20
H2AC4
H2AX
H3-4
HSF2BP
IMMT
KAT5
KMT2A
LRIF1
MAPK14
MLLT1
MUC1
NDEL1
PCBP2-OT1
PCGF3
PCGF6
PGR
PHC1
PHC2
PTN
RING1
RNF114
RNF2
RRM1
SOCS2
TRIM27
TUSC3
UBE2D2
UBE2D3
UBE2I
USP11
USP15
VPS11
WHRN
ZBTB16
Entrez ID
57332
648
HPRD ID
13006
01277
Ensembl ID
ENSG00000141570
ENSG00000168283
Uniprot IDs
Q9HC52
P35226
PDB IDs
2N4Q
3I91
5EQ0
2H0D
2NA1
3RPG
4R8P
5FR6
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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