RPGRIP1 and NPHP4

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (in vivo, two hybrid, in vitro)

		RPGRIP1	NPHP4
Description		RPGR interacting protein 1	nephrocystin 4
Image			No pdb structure
GO Annotations	Cellular Component	Axoneme Photoreceptor Connecting Cilium Ciliary Transition Zone Photoreceptor Distal Connecting Cilium	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Visual Perception Retinal Rod Cell Development Response To Stimulus Neural Precursor Cell Proliferation Non-motile Cilium Assembly	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone
Pathways			Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Refractive error ( 32231278) Superior temporal sulcus banks volume ( 31530798)	Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	2 interacting genes: NPHP1 RPGRIP1
Entrez ID		57096	261734
HPRD ID		05673	06238
Ensembl ID		ENSG00000092200	ENSG00000131697
Uniprot IDs		Q96KN7	B3KW36 O75161
PDB IDs		4QAM
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?