MAPK10 and CREBBP

Data Source:
BioGRID (two hybrid)

		MAPK10	CREBBP
Description		mitogen-activated protein kinase 10	CREB binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Chromatin DNA Binding MRF Binding Peptide-lysine-N-acetyltransferase Activity
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction JNK Cascade JUN Phosphorylation Response To Light Stimulus Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Smoothened Signaling Pathway Viral Process Histone Acetylation N-terminal Peptidyl-lysine Acetylation Protein Phosphopantetheinylation Regulation Of Lipid Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To UV Homeostatic Process Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein-containing Complex Assembly Regulation Of Cellular Response To Heat Beta-catenin-TCF Complex Assembly Histone Glutamine Methylation
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation
Drugs		Minocycline Pyrazolanthrone Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine 9-(4-Hydroxyphenyl)-2,7-Phenanthroline Phosphoaminophosphonic Acid-Adenylate Ester N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline Fostamatinib Halicin	9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases			Rubinstein-Taybi syndrome
GWAS		Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Cobalt levels ( 26025379) Diisocyanate-induced asthma ( 25918132) Gait speed in old age ( 28077804) Liver enzyme levels (alanine transaminase) ( 22001757) Multiple sclerosis ( 31604244) Peripheral artery disease ( 25009551) Response to cytidine analogues (gemcitabine) ( 24483146) Triglyceride levels ( 32203549 32154731)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Neutrophil count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Pre-treatment viral load in HIV-1 infection ( 31219150) QT interval ( 24952745) QT interval (drug interaction) ( 23459443) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: APP ARRB1 ARRB2 ATF2 BCL2L11 CDK5 CDKN1B CDKN2A CDKN2C CEP290 CREBBP DUSP10 DUSP16 DUSP9 ELK1 FBXO7 GTF3C1 HAX1 HDAC9 HNRNPK HRAS JUN KIF26A LDHA MAP2K4 MAPK8IP2 MAPK8IP3 MAPKBP1 MAPT MCL1 PKMYT1 PLIN2 RELA SH3BP5 STMN2 TNIP1 TP53 UNC119	295 interacting genes: ACTA2 ACVR1 AFP AIRE AKT1 ALX1 ANAPC5 ANAPC7 AP1B1 APC AR ATF1 ATF3 ATF4 ATF7IP ATRX BCL3 BCL6 BRCA1 BRIP1 CALCOCO1 CAMK4 CARM1 CASP8AP2 CBX4 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CHAF1A CHD3 CHUK CITED1 CITED2 CNOT3 CPSF4 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK DYRK1A E2F1 E2F3 E2F5 EBF1 EGR1 EID1 EID3 EIF2B1 EIF3D ELF3 ELK1 EP300 ESR1 ETS1 ETS2 EWSR1 FAF1 FBXL19 FBXO38 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 GABPA GAK GATA1 GATAD2A GCM1 GLI3 GMEB1 GMEB2 GTF2B H2BC21 H2BC3 H3-3A H3-4 H3C1 H4-16 H4C1 HBP1 HCK HDAC1 HDAC3 HIF1A HIPK1 HIPK2 HIPK3 HLF HMGA1 HMGB1 HMGB2 HMGXB4 HNF1A HNF1B HNF4A HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT IKBKG IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM3B KHDRBS1 KISS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP3K5 MAPK1 MAPK10 MAPK3 MAPT MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 ONECUT1 PARP1 PAX5 PBX1 PCMT1 PCNA PELP1 PHOX2A PIAS1 PIAS2 PIAS3 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PPP1R8 PPP2R2A PRKCD PRLR PROX1 PSME3 PTMA PTPRF RAD23A RBBP4 RBBP7 RBCK1 RELA RNF111 RPL3 RPL35 RPS6KA1 RPS6KA3 RPS6KA5 RXRG SERTAD1 SERTAD2 SERTAD3 SETDB1 SH3GL1 SMAD2 SMAD3 SMAD4 SND1 SNIP1 SOX9 SP100 SPI1 SPIB SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUMO1 SUV39H1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TOPORS TP53 TP73 TRERF1 TRIP10 TRIP4 TSPYL2 UBE2D1 UBE2I UBTF UIMC1 VDR WDR77 WT1 XAF1 XRCC6 YWHAH ZBTB17 ZBTB2 ZCCHC7 ZHX1 ZMYM2 ZMYM5 ZNF451 ZNF639 ZNFX1
Entrez ID		5602	1387
HPRD ID		04207	02534
Ensembl ID		ENSG00000109339	ENSG00000005339
Uniprot IDs		A0A1P0B7D2 A0A286YEQ7 A0A286YES0 A0A286YF02 A0A286YF97 A0A286YFD7 A0A286YFN2 D6RCB1 D6RJF9 F8W9R5 I6L9F3 P53779 Q499Y8	Q92793
PDB IDs		1JNK 1PMN 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N 3KVX 3OXI 3OY1 3PTG 3RTP 3TTI 3TTJ 3V6R 3V6S 4H36 4H39 4H3B 4KKE 4KKG 4KKH 4U79 4W4V 4W4W 4W4X 4W4Y 4WHZ 4X21 4Y46 4Y5H 4Z9L 6EKD 6EMH 6EQ9	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2N1A 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP 5DBM 5EIC 5ENG 5EP7 5GH9 5H85 5I83 5I86 5I89 5I8B 5I8G 5J0D 5JEM 5KTU 5KTW 5KTX 5LPJ 5LPL 5MME 5MMG 5MPK 5MPN 5MPZ 5MQE 5MQG 5MQK 5NLK 5NRW 5NU3 5OWK 5SVH 5TB6 5W0E 5W0F 5W0L 5W0Q 5XXH 6ALB 6ALC 6AXQ 6AY3 6AY5 6DMK 6ES5 6ES6 6ES7 6FQO 6FQT 6FQU 6FR0 6FRF 6QST 6SQE 6SQF 6SQM 6SXX 6YIJ 6YIK 6YIL 6YIM 7JFL 7JFM
Enriched GO Terms of Interacting Partners?
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