LAPTM4B and TMEM86B

Data Source:
BioGRID (two hybrid)

		LAPTM4B	TMEM86B
Description		lysosomal protein transmembrane 4 beta	transmembrane protein 86B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Multivesicular Body Membrane Cell Projection Multivesicular Body, Internal Vesicle	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding Ceramide Binding Phosphatidylinositol Bisphosphate Binding	Protein Binding Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity Alkenylglycerophosphoethanolamine Hydrolase Activity
	Biological Process	Endosome Organization Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Lysosome Organization	Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process
Pathways			Acyl chain remodelling of PC
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) QT interval ( 24952745)	Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Systemic lupus erythematosus ( 33536424 28714469)
Interacting Genes		21 interacting genes: BDKRB1 CGRRF1 CTXN3 CYB561A3 EMP1 GJA8 GPX8 IFNAR1 IGFBP5 ISLR2 MTIF3 NAALADL2 NRG1 ODF4 PIP5K1C SCARB2 SLC22A1 SLC22A2 SLC29A2 TMEM86B TRARG1	105 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22
Entrez ID		55353	255043
HPRD ID		13960	14540
Ensembl ID		ENSG00000104341	ENSG00000180089
Uniprot IDs		Q86VI4	Q8N661
PDB IDs
Enriched GO Terms of Interacting Partners?
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