TMEM86B and GJA4

Data Source:
BioGRID (two hybrid)

		TMEM86B	GJA4
Description		transmembrane protein 86B	gap junction protein alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Integral Component Of Plasma Membrane Gap Junction Connexin Complex
	Molecular Function	Protein Binding Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity Alkenylglycerophosphoethanolamine Hydrolase Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process	Blood Vessel Development Endothelium Development Calcium Ion Transport Cell-cell Junction Assembly Cell-cell Signaling Response To Pain Transmembrane Transport
Pathways		Acyl chain remodelling of PC	Gap junction assembly
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Systemic lupus erythematosus ( 33536424 28714469)	Formal thought disorder in schizophrenia ( 22648509) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		105 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22	5 interacting genes: CD81 MS4A13 OPRM1 SLC29A2 TMEM86B
Entrez ID		255043	2701
HPRD ID		14540	08509
Ensembl ID		ENSG00000180089	ENSG00000187513
Uniprot IDs		Q8N661	P35212
PDB IDs
Enriched GO Terms of Interacting Partners?
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