TMEM86B and LSS

Data Source:
BioGRID (two hybrid)

		TMEM86B	LSS
Description		transmembrane protein 86B	lanosterol synthase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Protein Binding Ether Hydrolase Activity Identical Protein Binding Alkenylglycerophosphocholine Hydrolase Activity Alkenylglycerophosphoethanolamine Hydrolase Activity	Lanosterol Synthase Activity Protein Binding Beta-amyrin Synthase Activity
	Biological Process	Phosphatidylcholine Acyl-chain Remodeling Ether Lipid Metabolic Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Triterpenoid Biosynthetic Process Regulation Of Protein Stability Regulation Of Cholesterol Biosynthetic Process
Pathways		Acyl chain remodelling of PC	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			R048-8071 Lanosterol
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Phosphatidylethanolamine-ether levels ( 31551469) Systemic lupus erythematosus ( 33536424 28714469)	White blood cell count ( 27863252)
Interacting Genes		105 interacting genes: AQP6 ARL13B ARL6IP6 ASGR2 BCL2L13 BIK BMP10 C2CD2L CCDC167 CCDC34 CCL4 CD53 CD79A CLRN1 CYB5B DHRSX DNAJC30 EBP ERGIC3 ERP29 EVI2B F11R FAM209A FAXDC2 FKBP7 FXYD6 GJA1 GJA4 GJA8 GOLM1 GPR37L1 GPX8 GUCA2A HIBADH HSD17B13 IER3IP1 IFITM3 KIR2DL3 LAPTM4B LIME1 LSS LY6D MARCHF2 MFF MGST3 MMGT1 MS4A14 MSMO1 MUC1 NDUFAF1 NEMP1 NINJ2 ORMDL2 OTULINL PEX11G PGRMC2 PIGF PLN PSCA PTPN1 PTPN9 RHBDD1 RHOT2 RPRM RTP2 SEC22B SERINC2 SFRP1 SFT2D1 SFXN5 SLC10A6 SLC29A2 SLC35G2 SLC39A9 SMIM1 SNORC SSMEM1 STOM STX12 STX6 STX8 TEX29 THAP4 THBD TIMM23 TMEM106A TMEM107 TMEM120A TMEM14A TMEM14C TMEM203 TMEM237 TMEM248 TMEM52B TMEM60 TMPRSS2 TMX2 TREX1 TSNARE1 USE1 VAMP2 VAMP3 VAMP5 VAPA ZDHHC22	9 interacting genes: AQP6 CIB1 GPR35 NR4A1 SLC10A1 SLC10A6 TMEM167B TMEM86B YIF1A
Entrez ID		255043	4047
HPRD ID		14540	02945
Ensembl ID		ENSG00000180089	ENSG00000160285
Uniprot IDs		Q8N661	B2R694 P48449
PDB IDs			1W6J 1W6K
Enriched GO Terms of Interacting Partners?
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