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TMEM86B and GJA1
Data Source:
BioGRID
(two hybrid)
TMEM86B
GJA1
Description
transmembrane protein 86B
gap junction protein alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Golgi Membrane
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Lysosome
Early Endosome
Multivesicular Body
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Fascia Adherens
Gap Junction
Connexin Complex
Focal Adhesion
Intercalated Disc
Apical Plasma Membrane
Cell Junction
Golgi-associated Vesicle Membrane
Intracellular Membrane-bounded Organelle
Cell-cell Contact Zone
Membrane Raft
Tight Junction
Molecular Function
Protein Binding
Ether Hydrolase Activity
Identical Protein Binding
Alkenylglycerophosphocholine Hydrolase Activity
Alkenylglycerophosphoethanolamine Hydrolase Activity
Gap Junction Channel Activity
Protein Binding
Beta-catenin Binding
Ion Transmembrane Transporter Activity
Efflux Transmembrane Transporter Activity
Tubulin Binding
SH3 Domain Binding
PDZ Domain Binding
Glutathione Transmembrane Transporter Activity
Gap Junction Hemi-channel Activity
Connexin Binding
Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling
Disordered Domain Specific Binding
Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
Biological Process
Phosphatidylcholine Acyl-chain Remodeling
Ether Lipid Metabolic Process
Establishment Of Mitotic Spindle Orientation
Negative Regulation Of Endothelial Cell Proliferation
Chronic Inflammatory Response
Response To Ischemia
Positive Regulation Of Glomerular Filtration
Endothelium Development
Apoptotic Process
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Spermatogenesis
Heart Development
Response To PH
Response To Glucose
Vascular Transport
Positive Regulation Of Gene Expression
Cell Communication By Electrical Coupling
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Cell Communication By Chemical Coupling
Glutamate Secretion
ATP Transport
Gap Junction Assembly
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Cell Growth
Positive Regulation Of Insulin Secretion
Negative Regulation Of Gonadotropin Secretion
Response To Estradiol
Response To Lipopolysaccharide
Response To Retinoic Acid
Ion Transmembrane Transport
Response To Fluid Shear Stress
Cellular Protein Localization
Glutathione Transmembrane Transport
Maintenance Of Protein Localization In Endoplasmic Reticulum
Maintenance Of Blood-brain Barrier
Xenobiotic Transport
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Peptide Hormone
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Vasoconstriction
Decidualization
Bone Remodeling
Neuron Projection Morphogenesis
Regulation Of Calcium Ion Transport
Negative Regulation Of Cardiac Muscle Cell Proliferation
Bone Development
Negative Regulation Of Wound Healing
Cellular Response To Mechanical Stimulus
Cellular Response To Parathyroid Hormone Stimulus
Atrial Cardiac Muscle Cell Action Potential
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Positive Regulation Of Cold-induced Thermogenesis
Export Across Plasma Membrane
Negative Regulation Of Trophoblast Cell Migration
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Morphogenesis Of An Epithelium
Positive Regulation Of Mesodermal Cell Differentiation
Epididymis Development
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Stem Cell Proliferation
Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Behavioral Fear Response
Pathways
Acyl chain remodelling of PC
Oligomerization of connexins into connexons
Transport of connexins along the secretory pathway
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
Gap junction assembly
Gap junction degradation
Regulation of gap junction activity
Regulation of gap junction activity
Formation of annular gap junctions
Drugs
Carvedilol
Diseases
Syndactyly
Deafness, autosomal recessive
Oculodentodigital dysplasia
GWAS
Mean reticulocyte volume (
32888494
)
Phosphatidylethanolamine-ether levels (
31551469
)
Systemic lupus erythematosus (
33536424
28714469
)
Atrial fibrillation (
28416818
28416822
29892015
)
Disease progression in age-related macular degeneration (
29346644
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Focal epilepsy (with hippocampal sclerosis) (
30531953
)
General risk tolerance (MTAG) (
30643258
)
HDL cholesterol levels (
32203549
)
Heart rate (
23583979
)
Heel bone mineral density (
30598549
)
Migraine (
27322543
)
Peak creatinine levels in vancomycin therapy (
26030142
)
PR interval (
32439900
)
Protein quantitative trait loci (
18464913
)
Pulse pressure (
28135244
27841878
)
Resting heart rate (
29769521
23183192
27798624
20639392
)
RR interval (heart rate) (
30679814
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Tendinopathy (
31615970
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
105 interacting genes:
AQP6
ARL13B
ARL6IP6
ASGR2
BCL2L13
BIK
BMP10
C2CD2L
CCDC167
CCDC34
CCL4
CD53
CD79A
CLRN1
CYB5B
DHRSX
DNAJC30
EBP
ERGIC3
ERP29
EVI2B
F11R
FAM209A
FAXDC2
FKBP7
FXYD6
GJA1
GJA4
GJA8
GOLM1
GPR37L1
GPX8
GUCA2A
HIBADH
HSD17B13
IER3IP1
IFITM3
KIR2DL3
LAPTM4B
LIME1
LSS
LY6D
MARCHF2
MFF
MGST3
MMGT1
MS4A14
MSMO1
MUC1
NDUFAF1
NEMP1
NINJ2
ORMDL2
OTULINL
PEX11G
PGRMC2
PIGF
PLN
PSCA
PTPN1
PTPN9
RHBDD1
RHOT2
RPRM
RTP2
SEC22B
SERINC2
SFRP1
SFT2D1
SFXN5
SLC10A6
SLC29A2
SLC35G2
SLC39A9
SMIM1
SNORC
SSMEM1
STOM
STX12
STX6
STX8
TEX29
THAP4
THBD
TIMM23
TMEM106A
TMEM107
TMEM120A
TMEM14A
TMEM14C
TMEM203
TMEM237
TMEM248
TMEM52B
TMEM60
TMPRSS2
TMX2
TREX1
TSNARE1
USE1
VAMP2
VAMP3
VAMP5
VAPA
ZDHHC22
26 interacting genes:
AKT1
CAV1
CCN3
CNST
CREB3
CSK
CSNK1D
GJA3
GJA5
HTR2C
MAPK1
MAPK3
MAPK7
NINJ2
PLPP4
PRKCA
PRKCB
PRKCE
PRKCG
S100A1
SGSM3
SRC
TJP1
TMEM128
TMEM86B
UBQLN4
Entrez ID
255043
2697
HPRD ID
14540
00414
Ensembl ID
ENSG00000180089
ENSG00000152661
Uniprot IDs
Q8N661
A0A654IBU3
P17302
PDB IDs
2LL2
Enriched GO Terms of Interacting Partners
?
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