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PPP2R1A and MAPK6
Data Source:
BioGRID
(two hybrid)
PPP2R1A
MAPK6
Description
protein phosphatase 2 scaffold subunit Aalpha
mitogen-activated protein kinase 6
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Chromosome Segregation
Mitotic Nuclear Envelope Reassembly
RNA Splicing
Response To Organic Substance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Cell Differentiation
Protein-containing Complex Assembly
Ciliary Basal Body-plasma Membrane Docking
MAPK Cascade
Protein Phosphorylation
Cell Cycle
Signal Transduction
Intracellular Signal Transduction
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
MAPK6/MAPK4 signaling
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Acetylsalicylic acid
Minocycline
Diseases
GWAS
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Interacting Genes
57 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP2R5D
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
166 interacting genes:
ACTG1
ACTR1B
AMPH
ANAPC5
ANK3
ANKRD2
APBA2
ARHGDIA
ARPC3
ATG9A
ATP5PF
BAG6
BARX1
BBS10
CA1
CA12
CALR
CASP6
CCND3
CCT3
CDH13
CERS1
CFAP298
CFL1
CNTN1
CNTRL
COPS6
CSE1L
CYRIB
CYTH2
DBN1
DCTN2
DDOST
DDR1
DGKZ
DKC1
DNAJC28
DPPA4
DST
DYNC2I2
EDF1
EEF1A2
EIF1
EIF3C
EIF4A1
ELOF1
EMD
FBXL16
FOXO3
FXYD3
GALNT7
GATA1
GLRX3
GORASP1
GPX1
HACL1
HAUS2
HDAC11
HIP1
HNRNPA0
HNRNPD
HNRNPH3
HSP90AB1
HSP90B1
HSPD1
IDH3B
INS
ITGB3BP
ITSN1
JUNB
KDSR
KLC1
KNSTRN
LPXN
MAP3K12
MAP3K7
MAPKAPK5
MASP1
MBIP
MBOAT7
MCM3
MDK
METTL17
METTL2A
MGAT1
MIPEP
MOK
MON1A
MTG2
MYBL2
MYOZ3
MZB1
NAT9
NAXE
NDUFS6
NECTIN2
NELFB
NOL4
NRXN2
NUDT5
OSTF1
PDCD6IP
PDLIM1
PHACTR3
PHC2
PHGDH
PIH1D1
PLEKHM1
PLSCR1
PPBP
PPP1R7
PPP2R1A
PRKAB1
PRKAR1A
PRKCB
PRPF38A
PSAT1
PSIP1
PTPMT1
RAB2A
RAB31
RACK1
RANBP9
RAP1GAP
RARA
RBL1
RGS19
RPL10
RRP7A
SEPTIN3
SEPTIN5
SERPINA4
SHC1
SLC20A1
SLC41A3
SMAD6
SMS
SNAPC4
SNW1
SOCS3
SPG7
SPRR2D
SPTAN1
SRSF5
STX7
TDP2
THAP4
TPI1
TTK
TUBA1A
UBA52
UBE2L3
URB1
USP20
VPS26C
WDR26
WFS1
WWC1
XPO1
ZNF133
ZNF205
ZNF331
ZNF579
ZNF600
ZNF671
ZNF775
Entrez ID
5518
5597
HPRD ID
16184
04213
Ensembl ID
ENSG00000105568
ENSG00000069956
Uniprot IDs
A8K7B7
P30153
Q16659
PDB IDs
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
6YKY
6YLC
6YLL
7AQB
Enriched GO Terms of Interacting Partners
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