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MAPK6 and PRKAR1A
Data Source:
BioGRID
(two hybrid)
MAPK6
PRKAR1A
Description
mitogen-activated protein kinase 6
protein kinase cAMP-dependent type I regulatory subunit alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Immunological Synapse
Cytoplasm
Multivesicular Body
Centrosome
Cytosol
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Protein-containing Complex
Plasma Membrane Raft
Sperm Connecting Piece
Ciliary Base
Glutamatergic Synapse
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
MAPK Cascade
Protein Phosphorylation
Cell Cycle
Signal Transduction
Intracellular Signal Transduction
Mesoderm Formation
Renal Water Homeostasis
Regulation Of Transcription By RNA Polymerase II
Female Meiotic Nuclear Division
Blood Coagulation
Regulation Of Protein Kinase A Signaling
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Regulation Of CAMP-mediated Signaling
Sarcomere Organization
Negative Regulation Of Meiotic Nuclear Division
Negative Regulation Of Activated T Cell Proliferation
Cardiac Muscle Cell Proliferation
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
MAPK6/MAPK4 signaling
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
Drugs
Acetylsalicylic acid
Minocycline
(Rp)-cAMPS
Cyclic GMP
Cyclic adenosine monophosphate
GEM-231
Diseases
Pigmented micronodular adrenocortical disease (PPNAD)
GWAS
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Body size at age 10 (
32376654
)
Coronary artery disease (
33020668
)
Estimated glomerular filtration rate (
31152163
)
Intake of total sugars (
31005972
)
Interacting Genes
166 interacting genes:
ACTG1
ACTR1B
AMPH
ANAPC5
ANK3
ANKRD2
APBA2
ARHGDIA
ARPC3
ATG9A
ATP5PF
BAG6
BARX1
BBS10
CA1
CA12
CALR
CASP6
CCND3
CCT3
CDH13
CERS1
CFAP298
CFL1
CNTN1
CNTRL
COPS6
CSE1L
CYRIB
CYTH2
DBN1
DCTN2
DDOST
DDR1
DGKZ
DKC1
DNAJC28
DPPA4
DST
DYNC2I2
EDF1
EEF1A2
EIF1
EIF3C
EIF4A1
ELOF1
EMD
FBXL16
FOXO3
FXYD3
GALNT7
GATA1
GLRX3
GORASP1
GPX1
HACL1
HAUS2
HDAC11
HIP1
HNRNPA0
HNRNPD
HNRNPH3
HSP90AB1
HSP90B1
HSPD1
IDH3B
INS
ITGB3BP
ITSN1
JUNB
KDSR
KLC1
KNSTRN
LPXN
MAP3K12
MAP3K7
MAPKAPK5
MASP1
MBIP
MBOAT7
MCM3
MDK
METTL17
METTL2A
MGAT1
MIPEP
MOK
MON1A
MTG2
MYBL2
MYOZ3
MZB1
NAT9
NAXE
NDUFS6
NECTIN2
NELFB
NOL4
NRXN2
NUDT5
OSTF1
PDCD6IP
PDLIM1
PHACTR3
PHC2
PHGDH
PIH1D1
PLEKHM1
PLSCR1
PPBP
PPP1R7
PPP2R1A
PRKAB1
PRKAR1A
PRKCB
PRPF38A
PSAT1
PSIP1
PTPMT1
RAB2A
RAB31
RACK1
RANBP9
RAP1GAP
RARA
RBL1
RGS19
RPL10
RRP7A
SEPTIN3
SEPTIN5
SERPINA4
SHC1
SLC20A1
SLC41A3
SMAD6
SMS
SNAPC4
SNW1
SOCS3
SPG7
SPRR2D
SPTAN1
SRSF5
STX7
TDP2
THAP4
TPI1
TTK
TUBA1A
UBA52
UBE2L3
URB1
USP20
VPS26C
WDR26
WFS1
WWC1
XPO1
ZNF133
ZNF205
ZNF331
ZNF579
ZNF600
ZNF671
ZNF775
47 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP4
AKAP5
AKAP7
ARFGEF2
BAHD1
C11orf49
C2orf88
CAPN11
CBS
CCNE1
CDK2
CDK4
DTX1
EGFR
FAM153B
GRB2
HIVEP1
HLA-A
ITGA4
MAPK6
MYO7A
NELL2
PATZ1
PJA2
PLEKHF2
PRKACA
PRKAR1B
PRKX
PRPF40A
PYCARD
RAF1
RFC2
RSPH3
SET
SETD7
SLC2A4
SMAD2
SPART
TAB1
TULP3
WDCP
WNK1
YWHAZ
ZBED1
Entrez ID
5597
5573
HPRD ID
04213
01786
Ensembl ID
ENSG00000069956
ENSG00000108946
Uniprot IDs
Q16659
B2R5T5
P10644
PDB IDs
6YKY
6YLC
6YLL
7AQB
5KJX
5KJY
5KJZ
Enriched GO Terms of Interacting Partners
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