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PPP2R1A and CSDC2
Data Source:
BioGRID
(two hybrid, two hybrid)
PPP2R1A
CSDC2
Description
protein phosphatase 2 scaffold subunit Aalpha
cold shock domain containing C2
Image
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Protein Serine/threonine Phosphatase Complex
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Extracellular Exosome
Nucleus
Cytoplasm
Molecular Function
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Transcription Factor Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Chromosome Segregation
Mitotic Nuclear Envelope Reassembly
RNA Splicing
Response To Organic Substance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Cell Differentiation
Protein-containing Complex Assembly
Ciliary Basal Body-plasma Membrane Docking
MRNA Processing
Regulation Of MRNA Stability
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Bitter non-alcoholic beverage consumption (
31046077
)
Meat-related diet (
32066663
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Schizophrenia (
28991256
)
Interacting Genes
57 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP2R5D
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
3 interacting genes:
INCA1
MEOX2
PPP2R1A
Entrez ID
5518
27254
HPRD ID
16184
15140
Ensembl ID
ENSG00000105568
ENSG00000172346
Uniprot IDs
A8K7B7
P30153
Q9Y534
PDB IDs
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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