Wiki-Pi
About
Search
Browse
People
Updates
Search
MAPK6 and GPX1
Data Source:
BioGRID
(two hybrid)
MAPK6
GPX1
Description
mitogen-activated protein kinase 6
glutathione peroxidase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Lewy Body
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Peroxidase Activity
Glutathione Peroxidase Activity
SH3 Domain Binding
Phospholipid-hydroperoxide Glutathione Peroxidase Activity
Biological Process
MAPK Cascade
Protein Phosphorylation
Cell Cycle
Signal Transduction
Intracellular Signal Transduction
Temperature Homeostasis
Endothelial Cell Development
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Purine Nucleotide Catabolic Process
Triglyceride Metabolic Process
Glutathione Metabolic Process
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Symbiotic Bacterium
UV Protection
Response To Selenium Ion
Response To Gamma Radiation
Protein Oxidation
Arachidonic Acid Metabolic Process
Lipoxygenase Pathway
Response To Hydroperoxide
Regulation Of Mammary Gland Epithelial Cell Proliferation
Cellular Response To Oxidative Stress
Regulation Of Gene Expression, Epigenetic
Vasodilation
Response To Hydrogen Peroxide
Hydrogen Peroxide Catabolic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Skeletal Muscle Tissue Regeneration
Blood Vessel Endothelial Cell Migration
Fat Cell Differentiation
Cell Redox Homeostasis
Skeletal Muscle Fiber Development
Myoblast Proliferation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Protein Kinase B Signaling
Heart Contraction
Angiogenesis Involved In Wound Healing
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Oxidant Detoxification
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Pathways
MAPK6/MAPK4 signaling
Synthesis of 5-eicosatetraenoic acids
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Detoxification of Reactive Oxygen Species
Purine catabolism
Drugs
Acetylsalicylic acid
Minocycline
Glutathione
Glutathione
Glutathione disulfide
Cannabidiol
Medical Cannabis
Nabiximols
Diseases
Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Blood protein levels (
28240269
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
21102463
)
Extremely high intelligence (
29520040
)
Hemoglobin levels (
32327693
)
Household income (MTAG) (
31844048
)
Inflammatory bowel disease (
28067908
23128233
)
Intelligence (MTAG) (
29326435
)
Mood instability (
31168069
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
25082827
)
Interacting Genes
166 interacting genes:
ACTG1
ACTR1B
AMPH
ANAPC5
ANK3
ANKRD2
APBA2
ARHGDIA
ARPC3
ATG9A
ATP5PF
BAG6
BARX1
BBS10
CA1
CA12
CALR
CASP6
CCND3
CCT3
CDH13
CERS1
CFAP298
CFL1
CNTN1
CNTRL
COPS6
CSE1L
CYRIB
CYTH2
DBN1
DCTN2
DDOST
DDR1
DGKZ
DKC1
DNAJC28
DPPA4
DST
DYNC2I2
EDF1
EEF1A2
EIF1
EIF3C
EIF4A1
ELOF1
EMD
FBXL16
FOXO3
FXYD3
GALNT7
GATA1
GLRX3
GORASP1
GPX1
HACL1
HAUS2
HDAC11
HIP1
HNRNPA0
HNRNPD
HNRNPH3
HSP90AB1
HSP90B1
HSPD1
IDH3B
INS
ITGB3BP
ITSN1
JUNB
KDSR
KLC1
KNSTRN
LPXN
MAP3K12
MAP3K7
MAPKAPK5
MASP1
MBIP
MBOAT7
MCM3
MDK
METTL17
METTL2A
MGAT1
MIPEP
MOK
MON1A
MTG2
MYBL2
MYOZ3
MZB1
NAT9
NAXE
NDUFS6
NECTIN2
NELFB
NOL4
NRXN2
NUDT5
OSTF1
PDCD6IP
PDLIM1
PHACTR3
PHC2
PHGDH
PIH1D1
PLEKHM1
PLSCR1
PPBP
PPP1R7
PPP2R1A
PRKAB1
PRKAR1A
PRKCB
PRPF38A
PSAT1
PSIP1
PTPMT1
RAB2A
RAB31
RACK1
RANBP9
RAP1GAP
RARA
RBL1
RGS19
RPL10
RRP7A
SEPTIN3
SEPTIN5
SERPINA4
SHC1
SLC20A1
SLC41A3
SMAD6
SMS
SNAPC4
SNW1
SOCS3
SPG7
SPRR2D
SPTAN1
SRSF5
STX7
TDP2
THAP4
TPI1
TTK
TUBA1A
UBA52
UBE2L3
URB1
USP20
VPS26C
WDR26
WFS1
WWC1
XPO1
ZNF133
ZNF205
ZNF331
ZNF579
ZNF600
ZNF671
ZNF775
5 interacting genes:
ABL1
ABL2
FAM9B
MAPK6
SELENBP1
Entrez ID
5597
2876
HPRD ID
04213
11749
Ensembl ID
ENSG00000069956
ENSG00000233276
Uniprot IDs
Q16659
A0A2R8Y6B6
P07203
Q7L4Q3
PDB IDs
6YKY
6YLC
6YLL
7AQB
2F8A
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?