SLX1A and SLX4

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique)
HPRD (two hybrid)

		SLX1A	SLX4
Description		SLX1 homolog A, structure-specific endonuclease subunit	SLX4 structure-specific endonuclease subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Slx1-Slx4 Complex	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Interstrand Cross-link Repair Telomeric D-loop Disassembly Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Type 2 diabetes ( 32499647)
Interacting Genes		6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		548593	84464
HPRD ID		18681	12537
Ensembl ID		ENSG00000132207	ENSG00000188827
Uniprot IDs		Q9BQ83	Q8IY92
PDB IDs			4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?