SLX1A and EME1

Data Source:
BioGRID (pull down)

		SLX1A	EME1
Description		SLX1 homolog A, structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Slx1-Slx4 Complex	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Interstrand Cross-link Repair Telomeric D-loop Disassembly Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2
Entrez ID		548593	146956
HPRD ID		18681	10937
Ensembl ID		ENSG00000132207	ENSG00000154920
Uniprot IDs		Q9BQ83	Q96AY2
PDB IDs			2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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