SLX4

Description		SLX4 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Type 2 diabetes ( 32499647)
Novel Interacting Genes		1 novel interacting genes: GLIS2
Interacting Genes		8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		84464
HPRD ID		12537
Ensembl ID		ENSG00000188827
Uniprot IDs		Q8IY92
PDB IDs		4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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