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EME1 and SLX1A
Data Source:
BioGRID
(pull down)
EME1
SLX1A
Description
essential meiotic structure-specific endonuclease 1
SLX1 homolog A, structure-specific endonuclease subunit
Image
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleoplasm
Nucleolus
Holliday Junction Resolvase Complex
Nucleoplasm
Slx1-Slx4 Complex
Molecular Function
DNA Binding
Endonuclease Activity
Protein Binding
Metal Ion Binding
Protein Binding
Crossover Junction Endodeoxyribonuclease Activity
5'-flap Endonuclease Activity
Metal Ion Binding
Biological Process
Resolution Of Meiotic Recombination Intermediates
Double-strand Break Repair
Replication Fork Processing
Intra-S DNA Damage Checkpoint
Interstrand Cross-link Repair
Response To Intra-S DNA Damage Checkpoint Signaling
Nucleic Acid Phosphodiester Bond Hydrolysis
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Telomere Maintenance Via Telomere Lengthening
Interstrand Cross-link Repair
Telomeric D-loop Disassembly
Nucleic Acid Phosphodiester Bond Hydrolysis
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of T-circle Formation
Pathways
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
6 interacting genes:
APP
DDB1
MUS81
SLX1A
SLX4
SUMO2
6 interacting genes:
EME1
ERCC1
ERCC4
GRB2
MUS81
SLX4
Entrez ID
146956
548593
HPRD ID
10937
18681
Ensembl ID
ENSG00000154920
ENSG00000132207
Uniprot IDs
Q96AY2
Q9BQ83
PDB IDs
2ZIU
2ZIV
2ZIW
2ZIX
4P0P
4P0Q
4P0R
4P0S
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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