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POLA1 and GLRA2
Data Source:
HPRD
(in vitro)
POLA1
GLRA2
Description
DNA polymerase alpha 1, catalytic subunit
glycine receptor alpha 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytosol
Nuclear Matrix
Plasma Membrane
Integral Component Of Plasma Membrane
Chloride Channel Complex
Neuron Projection
Synapse
Postsynaptic Membrane
Glycinergic Synapse
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Purine Nucleotide Binding
Pyrimidine Nucleotide Binding
Protein Kinase Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Transmembrane Signaling Receptor Activity
Chloride Channel Activity
Glycine Binding
Extracellularly Glycine-gated Chloride Channel Activity
Glycine-gated Chloride Ion Channel Activity
Neurotransmitter Receptor Activity
Metal Ion Binding
Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Viral Process
Telomere Maintenance Via Semi-conservative Replication
Regulation Of Type I Interferon Production
Mitotic DNA Replication Initiation
DNA Synthesis Involved In UV-damage Excision Repair
Signal Transduction
Neuropeptide Signaling Pathway
Chemical Synaptic Transmission
Ion Transmembrane Transport
Regulation Of Membrane Potential
Response To Amino Acid
Nervous System Process
Synaptic Transmission, Glycinergic
Excitatory Postsynaptic Potential
Cellular Response To Amino Acid Stimulus
Cellular Response To Zinc Ion
Cellular Response To Ethanol
Chloride Transmembrane Transport
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
Neurotransmitter receptors and postsynaptic signal transmission
Neurotransmitter receptors and postsynaptic signal transmission
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Glycine
Lindane
Picrotoxin
Ethanol
Memantine
Taurine
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet count (
32888494
)
Interacting Genes
20 interacting genes:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
PRIM2
RAD51
RB1
RBMS1
SERPINA3
SMC1A
SUMO2
TP53
XRCC5
5 interacting genes:
BAG6
DDX24
GDI2
PSD
SEC23A
Entrez ID
5422
2742
HPRD ID
02416
02379
Ensembl ID
ENSG00000101868
ENSG00000101958
Uniprot IDs
A6NMQ1
P09884
P23416
PDB IDs
1K0P
1K18
1N5G
4Q5V
4QCL
4Y97
5EXR
5IUD
6AS7
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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