POLA1 and GINS4

Data Source:
BioGRID (pull down)

		POLA1	GINS4
Description		DNA polymerase alpha 1, catalytic subunit	GINS complex subunit 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	GINS Complex Nucleoplasm Cytoplasm CMG Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription	Unwinding of DNA Unwinding of DNA
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		20 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	17 interacting genes: BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1 SIK1B
Entrez ID		5422	84296
HPRD ID		02416	11583
Ensembl ID		ENSG00000101868	ENSG00000147536
Uniprot IDs		A6NMQ1 P09884	Q9BRT9
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	2E9X 2EHO 2Q9Q 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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