GLRA2 and GDI2

Data Source:
BioGRID (two hybrid)

		GLRA2	GDI2
Description		glycine receptor alpha 2	GDP dissociation inhibitor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Glycinergic Synapse	Extracellular Region Cytoplasm Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Glycine-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity Metal Ion Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	RNA Binding Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Response To Amino Acid Nervous System Process Synaptic Transmission, Glycinergic Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Neutrophil Degranulation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission	Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs
Drugs		Glycine Lindane Picrotoxin Ethanol Memantine Taurine
Diseases
GWAS			Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Osteosarcoma ( 23727862)
Interacting Genes		5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A	9 interacting genes: GLRA2 HSPB1 LINC01554 RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A
Entrez ID		2742	2665
HPRD ID		02379	02863
Ensembl ID		ENSG00000101958	ENSG00000057608
Uniprot IDs		P23416	P50395 Q6IAT1
PDB IDs
Enriched GO Terms of Interacting Partners?
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