POLA1 and POLA2

Data Source:
HPRD (in vivo, in vitro)

		POLA1	POLA2
Description		DNA polymerase alpha 1, catalytic subunit	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Cladribine Clofarabine Fludarabine Nelarabine	Dacarbazine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Acne (severe) ( 24927181) Serum uric acid levels ( 32514006)
Interacting Genes		20 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		5422	23649
HPRD ID		02416	10160
Ensembl ID		ENSG00000101868	ENSG00000014138
Uniprot IDs		A6NMQ1 P09884	Q14181
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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