PPIL3 and TAB3

Data Source:
BioGRID (pull down, unspecified method)

		PPIL3	TAB3
Description		peptidylprolyl isomerase like 3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding	Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Negative Regulation Of Autophagy Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3	10 interacting genes: CEP57L1 IKBKG MAP3K7 MAP3K7CL OGT PIN1 PPIL3 TAB1 TRAF2 TRAF6
Entrez ID		53938	257397
HPRD ID		15163	06738
Ensembl ID		ENSG00000240344	ENSG00000157625
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	Q8N5C8
PDB IDs		1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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