TAB3 and MAP3K7CL

Data Source:
HPRD (two hybrid)

		TAB3	MAP3K7CL
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 3	MAP3K7 C-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Nucleus Cytosol
	Molecular Function	Protein Binding Ubiquitin Binding Metal Ion Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Negative Regulation Of Autophagy Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Gamma glutamyl transferase levels ( 29403010) Ventricular ectopy ( 29618737) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CEP57L1 IKBKG MAP3K7 MAP3K7CL OGT PIN1 PPIL3 TAB1 TRAF2 TRAF6	9 interacting genes: AK8 CISH DDIT4L GPS2 KRT31 KRT34 REL TAB3 USF1
Entrez ID		257397	56911
HPRD ID		06738	10764
Ensembl ID		ENSG00000157625	ENSG00000156265
Uniprot IDs		Q8N5C8	B0EVZ6 B0EVZ7 B0EVZ8 B4DFW0 P57077
PDB IDs
Enriched GO Terms of Interacting Partners?
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