TAB3 and PPIL3

Data Source:
BioGRID (pull down, unspecified method)

		TAB3	PPIL3
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 3	peptidylprolyl isomerase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Ubiquitin Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Negative Regulation Of Autophagy Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: CEP57L1 IKBKG MAP3K7 MAP3K7CL OGT PIN1 PPIL3 TAB1 TRAF2 TRAF6	6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3
Entrez ID		257397	53938
HPRD ID		06738	15163
Ensembl ID		ENSG00000157625	ENSG00000240344
Uniprot IDs		Q8N5C8	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs			1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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