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PLK1 and TPT1
Data Source:
HPRD
(in vivo, in vitro)
PLK1
TPT1
Description
polo like kinase 1
tumor protein, translationally-controlled 1
Image
GO Annotations
Cellular Component
Kinetochore
Chromatin
Synaptonemal Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Spindle Pole
Extracellular Space
Nucleus
Cytoplasm
Multivesicular Body
Cytosol
Cytoplasmic Microtubule
Extracellular Exosome
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Protein Kinase Binding
Identical Protein Binding
RNA Binding
Calcium Ion Binding
Protein Binding
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Cytokinesis
Microtubule Bundle Formation
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Sister Chromatid Cohesion
Mitotic Nuclear Envelope Disassembly
Mitotic Spindle Assembly Checkpoint
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Peptidyl-threonine Phosphorylation
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Regulation Of Protein Binding
Homologous Chromosome Segregation
Establishment Of Protein Localization
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Proteolysis
Nuclear Envelope Disassembly
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein Localization To Nuclear Envelope
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Response To Virus
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
GWAS
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Type 2 diabetes (
25760438
)
Interacting Genes
120 interacting genes:
-
ACTL6B
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
BUB1B
C6orf136
CCDC115
CCNB1
CDC14A
CDC25C
CENPQ
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
DNAJB9
DNHD1
ECT2
EIF6
FBXL5
FBXW7
FZR1
GET4
GLB1
GORASP1
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRBA1
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MPP2
MYC
MYT1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PLK3
PPID
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PTEN
PTPRD
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RXRA
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STK3
STUB1
SUGT1
TANK
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
USP16
USP7
VRK3
WEE1
ZNF71
30 interacting genes:
APP
ATP1A1
ATP1A2
BCL2L1
CALM1
DBN1
EEF1A1
EEF1A2
EEF1B2
EEF1D
FANCA
HSPB1
IKBKG
LIG4
MCL1
MCPH1
MDM2
MLC1
NKX3-1
NOTCH3
PER2
PLK1
RBBP6
RPLP1
SNX6
SPP1
STEAP3
TRIP13
TUBB2A
VHL
Entrez ID
5347
7178
HPRD ID
03652
15979
Ensembl ID
ENSG00000166851
ENSG00000133112
Uniprot IDs
P53350
A0A024RDY2
A0A0B4J2C3
A0A0P1J1R0
P13693
PDB IDs
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
1YZ1
2HR9
3EBM
4Z9V
5O9L
5O9M
6IZB
6IZE
Enriched GO Terms of Interacting Partners
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