TPT1 and NOTCH3

Data Source:
BioGRID (pull down)

		TPT1	NOTCH3
Description		tumor protein, translationally-controlled 1	notch receptor 3
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GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Axon Guidance Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Type 2 diabetes ( 25760438)	Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1A2 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A VHL	48 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		7178	4854
HPRD ID		15979	02607
Ensembl ID		ENSG00000133112	ENSG00000074181
Uniprot IDs		A0A024RDY2 A0A0B4J2C3 A0A0P1J1R0 P13693	Q9UM47
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE	4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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