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TPT1 and SPP1
Data Source:
BioGRID
(two hybrid)
TPT1
SPP1
Description
tumor protein, translationally-controlled 1
secreted phosphoprotein 1
Image
GO Annotations
Cellular Component
Spindle Pole
Extracellular Space
Nucleus
Cytoplasm
Multivesicular Body
Cytosol
Cytoplasmic Microtubule
Extracellular Exosome
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
RNA Binding
Calcium Ion Binding
Protein Binding
Cytokine Activity
Integrin Binding
Protein Binding
Extracellular Matrix Binding
Biological Process
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Response To Virus
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Osteoblast Differentiation
Androgen Catabolic Process
Inflammatory Response
Cell Adhesion
Signal Transduction
Embryo Implantation
Extracellular Matrix Organization
Biomineral Tissue Development
Response To Vitamin D
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Bone Resorption
Positive Regulation Of Transcription, DNA-templated
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Positive Regulation Of Estradiol Secretion
Pathways
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
GWAS
Type 2 diabetes (
25760438
)
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Urate levels (
31578528
)
Interacting Genes
30 interacting genes:
APP
ATP1A1
ATP1A2
BCL2L1
CALM1
DBN1
EEF1A1
EEF1A2
EEF1B2
EEF1D
FANCA
HSPB1
IKBKG
LIG4
MCL1
MCPH1
MDM2
MLC1
NKX3-1
NOTCH3
PER2
PLK1
RBBP6
RPLP1
SNX6
SPP1
STEAP3
TRIP13
TUBB2A
VHL
97 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
C2orf50
CACNG4
CALM1
CC2D1B
CCR8
CD44
CEP162
CHD1
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DRD2
DSEL
EEF1A1
EIF3K
EPAS1
ERBB2
F2
FTH1
GET3
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCS1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
PTGER4
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SGTB
SLC22A1
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
Entrez ID
7178
6696
HPRD ID
15979
01325
Ensembl ID
ENSG00000133112
ENSG00000118785
Uniprot IDs
A0A024RDY2
A0A0B4J2C3
A0A0P1J1R0
P13693
A0A024RDE2
A0A024RDE6
A0A024RDJ0
B7Z351
P10451
Q3LGB0
PDB IDs
1YZ1
2HR9
3EBM
4Z9V
5O9L
5O9M
6IZB
6IZE
3CXD
3DSF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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