CD244 and CD247

Data Source:
HPRD (in vitro)

		CD244	CD247
Description		CD244 molecule	CD247 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Signal Transduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Leukocyte Migration Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface
Pathways		Cell surface interactions at the vascular wall
Drugs			Muromonab
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)
Interacting Genes		5 interacting genes: ARHGEF7 CD247 CD48 LAT SH2D1B	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		51744	919
HPRD ID		16121	01729
Ensembl ID		ENSG00000122223	ENSG00000198821
Uniprot IDs		Q9BZW8	P20963
PDB IDs			1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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