CD247 and SH2B3

Data Source:
HPRD (in vivo)

		CD247	SH2B3
Description		CD247 molecule	SH2B adaptor protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Cytosol Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Stem Cell Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface	Neutrophil Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Negative Regulation Of Cell Population Proliferation Embryonic Hemopoiesis Intracellular Signal Transduction Monocyte Homeostasis Megakaryocyte Development Cellular Response To Interleukin-3 Thrombopoietin-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Erythrocyte Development Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Negative Regulation Of Kit Signaling Pathway Cellular Response To Chemokine
Pathways			Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production
Drugs		Muromonab	Pazopanib
Diseases			Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)	Allergic rhinitis ( 30013184) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 29273807) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430479 19430483 27841878 21909115 28739976 27618447 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 19198610 32888494) Fibrinogen levels ( 28107422 26561523) Gastroesophageal reflux disease ( 31527586) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) IgA levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 31959993) Ischemic stroke ( 24262325 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Left ventricular end-diastolic volume ( 32382064) Lymphocyte counts ( 32888494 27863252) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 28017375) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 26343387) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 22139419 24026423 32888494 25705162 20139978 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763 27992413) Reaction time ( 27046643) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 30423114 24390342 20453842) Sarcoidosis ( 26051272) Small vessel stroke (CCS or TOAST classification) ( 32047268) Small vessel stroke (CCSp classification) ( 32047268) Stroke ( 29531354) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338) Systolic blood pressure ( 19430479 27841878 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 27182965 28928442) Tumor necrosis factor levels ( 32805626) Type 1 diabetes ( 21829393 25751624 19430480 17554300 30572963) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 32499647) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	12 interacting genes: CD247 EGFR ERBB2 ERBB3 ERBB4 FLNA GRB2 KIT LCK MET TNS2 ZAP70
Entrez ID		919	10019
HPRD ID		01729	05480
Ensembl ID		ENSG00000198821	ENSG00000111252
Uniprot IDs		P20963	B7Z7K6 F5GYM4 Q59H48 Q96BA5 Q9UQQ2
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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