CD244 and SH2D1B

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CD244	SH2D1B
Description		CD244 molecule	SH2 domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Signal Transduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Leukocyte Migration Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)	Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)
Interacting Genes		5 interacting genes: ARHGEF7 CD247 CD48 LAT SH2D1B	25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		51744	117157
HPRD ID		16121	12248
Ensembl ID		ENSG00000122223	ENSG00000198574
Uniprot IDs		Q9BZW8	O14796
PDB IDs			5KAZ
Enriched GO Terms of Interacting Partners?
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