CD247 and PI4K2B

Data Source:
HPRD (in vivo, in vitro)

		CD247	PI4K2B
Description		CD247 molecule	phosphatidylinositol 4-kinase type 2 beta
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Endosome Trans-Golgi Network Cytosol Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding	1-phosphatidylinositol 4-kinase Activity ATP Binding
	Biological Process	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface	Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphorylation
Pathways			Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs		Muromonab	Resveratrol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)	Attention deficit hyperactivity disorder ( 30563984) Cannabis dependence symptom count ( 27028160) Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281	4 interacting genes: AKT1 CASR CD247 MAPK14
Entrez ID		919	55300
HPRD ID		01729	15132
Ensembl ID		ENSG00000198821	ENSG00000038210
Uniprot IDs		P20963	G5E9Z4 Q8TCG2
PDB IDs		1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR	4WTV
Enriched GO Terms of Interacting Partners?
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