ORC4 and FBXL5

Data Source:
BioGRID (two hybrid)

		ORC4	FBXL5
Description		origin recognition complex subunit 4	F-box and leucine rich repeat protein 5
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation	Protein Polyubiquitination Cellular Iron Ion Homeostasis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4	11 interacting genes: CITED2 CSNK2B DCTN1 EP300 IREB2 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
Entrez ID		5000	26234
HPRD ID		09118	05739
Ensembl ID		ENSG00000115947	ENSG00000118564
Uniprot IDs		A8K7H4 O43929 Q96B14	Q9UKA1
PDB IDs		5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
Enriched GO Terms of Interacting Partners?
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