ORC4 and FBXO6

Data Source:
BioGRID (two hybrid)

		ORC4	FBXO6
Description		origin recognition complex subunit 4	F-box protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation	DNA Damage Checkpoint Protein Polyubiquitination DNA Repair Proteolysis Glycoprotein Catabolic Process Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4	3 interacting genes: ORC4 RIOK1 SKP1
Entrez ID		5000	26270
HPRD ID		09118	07291
Ensembl ID		ENSG00000115947	ENSG00000116663
Uniprot IDs		A8K7H4 O43929 Q96B14	Q9NRD1
PDB IDs		5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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