FBXL5 and ORC4

Data Source:
BioGRID (two hybrid)

		FBXL5	ORC4
Description		F-box and leucine rich repeat protein 5	origin recognition complex subunit 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Protein Polyubiquitination Cellular Iron Ion Homeostasis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)	Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		11 interacting genes: CITED2 CSNK2B DCTN1 EP300 IREB2 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		26234	5000
HPRD ID		05739	09118
Ensembl ID		ENSG00000118564	ENSG00000115947
Uniprot IDs		Q9UKA1	A8K7H4 O43929 Q96B14
PDB IDs		3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD	5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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