ASNS and TRIM69

Data Source:
BioGRID (two hybrid, two hybrid)

		ASNS	TRIM69
Description		asparagine synthetase (glutamine-hydrolyzing)	tripartite motif containing 69
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GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Asparagine Synthase (glutamine-hydrolyzing) Activity Protein Binding ATP Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Liver Development Asparagine Biosynthetic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Response To Light Stimulus Response To Mechanical Stimulus Response To Toxic Substance Response To Methotrexate Response To Follicle-stimulating Hormone Cellular Response To Hormone Stimulus PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Aspartic acid Glutamic acid ATP Asparagine
Diseases
GWAS		Regular attendance at a religious group ( 29970889) Tuberculosis ( 30713548)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		5 interacting genes: ATXN1 STRN4 SUMO2 TRIM69 WDR27	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		440	140691
HPRD ID		00153	11518
Ensembl ID		ENSG00000070669	ENSG00000185880
Uniprot IDs		P08243	H0YL66 Q86WT6
PDB IDs		6GQ3	4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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