MME and GAST

Data Source:
HPRD (in vitro)

		MME	GAST
Description		membrane metalloendopeptidase	gastrin
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Integral Component Of Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse	Extracellular Region Extracellular Space
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Peptide Binding Protein Homodimerization Activity Oligopeptidase Activity Cardiolipin Binding	Hormone Activity Protein Binding
	Biological Process	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Aging Learning Or Memory Protein Processing Sensory Perception Of Pain Lung Development Neutrophil Degranulation Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation	Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Food
Pathways		Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation	G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat	Oxetacaine
Diseases
GWAS		Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878)
Interacting Genes		18 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 VIP	24 interacting genes: AQP6 AQP9 ASPH BCL2L13 CISD2 CP CPE CREB3L1 CYB5R3 ERGIC3 FAM209A GOLM1 GPR152 KIR2DL3 KRT34 LHFPL2 MEP1B MMD MME MUC1 PDZK1IP1 PLP1 SLC10A1 TMEM52B
Entrez ID		4311	2520
HPRD ID		00392	00671
Ensembl ID		ENSG00000196549	ENSG00000184502
Uniprot IDs		P08473	A0A0E3VY36 P01350
PDB IDs		1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP	5WRJ
Enriched GO Terms of Interacting Partners?
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