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MME and ADCYAP1
Data Source:
HPRD
(in vitro)
MME
ADCYAP1
Description
membrane metalloendopeptidase
adenylate cyclase activating polypeptide 1
Image
GO Annotations
Cellular Component
Cytoplasm
Early Endosome
Trans-Golgi Network
Plasma Membrane
Integral Component Of Plasma Membrane
Brush Border
Focal Adhesion
Synaptic Vesicle
Cell Surface
Integral Component Of Membrane
Axon
Dendrite
Secretory Granule Membrane
Cytoplasmic Vesicle
Neuronal Cell Body
Neuron Projection Terminus
Membrane Raft
Synapse
Extracellular Exosome
Presynapse
Extracellular Region
Extracellular Space
Neuron Projection
Terminal Bouton
Perikaryon
Molecular Function
Phosphatidylserine Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Protein Binding
Metallopeptidase Activity
Exopeptidase Activity
Zinc Ion Binding
Peptide Binding
Protein Homodimerization Activity
Oligopeptidase Activity
Cardiolipin Binding
Signaling Receptor Binding
Neuropeptide Hormone Activity
Protein Binding
Pituitary Adenylate Cyclase Activating Polypeptide Activity
Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding
Peptide Hormone Receptor Binding
Biological Process
Kidney Development
Placenta Development
Angiotensin Maturation
Proteolysis
Peptide Metabolic Process
Aging
Learning Or Memory
Protein Processing
Sensory Perception Of Pain
Lung Development
Neutrophil Degranulation
Creatinine Metabolic Process
Amyloid-beta Metabolic Process
Positive Regulation Of Neurogenesis
Neuropeptide Processing
Cellular Response To Cytokine Stimulus
Cellular Response To UV-A
Cellular Response To UV-B
Replicative Senescence
Amyloid-beta Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of Long-term Synaptic Potentiation
Ovarian Follicle Development
Behavioral Fear Response
Histamine Secretion
Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Neuropeptide Signaling Pathway
Cell-cell Signaling
Female Pregnancy
Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Sensory Perception Of Pain
CAMP-mediated Signaling
Pituitary Gland Development
Insulin Secretion
Neuron Projection Development
Positive Regulation Of Interleukin-6 Production
Regulation Of Protein Localization
Negative Regulation Of GTPase Activity
Response To Starvation
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of GTPase Activity
Positive Regulation Of CAMP-mediated Signaling
Response To Ethanol
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
ATP Metabolic Process
Positive Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Postsynaptic Membrane Potential
Positive Regulation Of Growth Hormone Secretion
Negative Regulation Of Glial Cell Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Oligodendrocyte Progenitor Proliferation
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Somatostatin Secretion
Positive Regulation Of Cold-induced Thermogenesis
Pathways
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation
NGF-independant TRKA activation
G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Candoxatril
Omapatrilat
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
Phosphoramidon
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
[2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala
Daglutril
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
Thiorphan
Sacubitril
Candoxatrilat
2,6-Diamino-Hexanoic Acid Amide
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Primary sclerosing cholangitis (
27992413
)
Systolic blood pressure (
27841878
)
Body size at age 10 (
32376654
)
Chronotype (
30696823
)
Midgestational cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Obesity-related traits (
23251661
)
Very long-chain saturated fatty acid levels (fatty acid 22:0) (
25378659
)
Interacting Genes
18 interacting genes:
ADCYAP1
ADM
AGT
CSNK2A1
CSNK2B
EDN1
EDN2
EZR
GAST
LYN
NDRG1
NPPA
NPPC
PIK3CB
PIK3R1
PTEN
SHC1
VIP
8 interacting genes:
ADCYAP1R1
CASP2
CPAMD8
MME
SCTR
SHH
VIPR1
VIPR2
Entrez ID
4311
116
HPRD ID
00392
02369
Ensembl ID
ENSG00000196549
ENSG00000141433
Uniprot IDs
P08473
B7Z222
P18509
PDB IDs
1DL9
1DMT
1QVD
1R1H
1R1I
1R1J
1Y8J
2QPJ
2YB9
4CTH
5JMY
6GID
6SH1
6SH2
6SUK
6SVY
6THP
6XVP
1GEA
2D2P
2JOD
6LPB
6M1I
6P9Y
6VN7
Enriched GO Terms of Interacting Partners
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