MCM6 and ORC4

Data Source:
BioGRID (two hybrid)

		MCM6	ORC4
Description		minichromosome maintenance complex component 6	origin recognition complex subunit 4
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Body mass index ( 25673413) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		38 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 UBE3A ZBTB9	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		4175	5000
HPRD ID		03485	09118
Ensembl ID		ENSG00000076003	ENSG00000115947
Uniprot IDs		Q14566	A8K7H4 O43929 Q96B14
PDB IDs		2KLQ 2LE8 6XTX 6XTY	5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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