MCM6 and ORC6

Data Source:
HPRD (in vitro)

		MCM6	ORC6
Description		minichromosome maintenance complex component 6	origin recognition complex subunit 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex	Origin Recognition Complex Fibrillar Center Nucleoplasm Nuclear Origin Of Replication Recognition Complex Membrane
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity	DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Negative Regulation Of Cell Division
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Body mass index ( 25673413) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		38 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 UBE3A ZBTB9	19 interacting genes: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2
Entrez ID		4175	23594
HPRD ID		03485	06237
Ensembl ID		ENSG00000076003	ENSG00000091651
Uniprot IDs		Q14566	A0A024R6R3 Q9Y5N6
PDB IDs		2KLQ 2LE8 6XTX 6XTY	3M03 6KVG
Enriched GO Terms of Interacting Partners?
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