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MCM3 and LZTR1
Data Source:
BioGRID
(two hybrid)
MCM3
LZTR1
Description
minichromosome maintenance complex component 3
leucine zipper like transcription regulator 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Centrosome
Membrane
MCM Complex
Perinuclear Region Of Cytoplasm
CMG Complex
Golgi Apparatus
Endomembrane System
Cul3-RING Ubiquitin Ligase Complex
Recycling Endosome Membrane
Molecular Function
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein Binding
Small GTPase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
DNA Duplex Unwinding
Mitotic DNA Replication Initiation
Protein Ubiquitination
Negative Regulation Of Ras Protein Signal Transduction
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Drugs
Diseases
GWAS
Interacting Genes
36 interacting genes:
CCNE1
CDC45
CDC5L
CDC6
CDC7
CDK2
CSNK2A1
DBF4
EP300
HAUS1
KEAP1
LZTR1
MAPK6
MCM10
MCM2
MCM3AP
MCM4
MCM5
MCM6
MCM7
MCMBP
ORC2
ORC4
ORC5
PLK1
POLR2A
PPP2R1A
PPP2R1B
PTEN
RAD52
STAT1
SUMO2
SUPT16H
SYF2
TRIM28
YWHAQ
55 interacting genes:
AATF
ANKRD53
ASB12
BMPR1B
CEBPZ
CHAF1A
CNOT6L
E2F8
EHMT1
FANK1
GABARAPL2
HCLS1
HDAC4
HRAS
IKBKG
KDM2B
KRAS
L3MBTL3
MCM3
MED16
MED7
MYBL2
NR1H3
NRAS
PAPOLG
PARP1
POLR1B
POLR2B
POLR2E
RAI1
RERE
RIT1
RUVBL1
SCMH1
SND1
SP100
SREBF2
SSX4
STAT1
SUGP2
TAF11
TBX2
TCF19
TFAP2B
TRIM5
TUBGCP4
WWP1
ZBTB1
ZNF137P
ZNF175
ZNF451
ZNF490
ZNF584
ZNF714
ZZZ3
Entrez ID
4172
8216
HPRD ID
04072
08992
Ensembl ID
ENSG00000112118
ENSG00000099949
Uniprot IDs
A0A0S2Z4T1
A0A499FHX9
B4DUQ9
P25205
A0A384NL67
Q8N653
PDB IDs
6XTX
6XTY
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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