ARSA and PROP1

Data Source:
BioGRID (two hybrid)

		ARSA	PROP1
Description		arylsulfatase A	PROP paired-like homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Glycosphingolipid Metabolic Process Neutrophil Degranulation	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Pituitary Gland Development
Pathways		Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation
Drugs		4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		Metachromatic leukodystrophy (MLD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)
Interacting Genes		18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX	54 interacting genes: ABHD11 ARSA BATF2 C11orf1 C19orf54 C1orf94 C6orf15 C9orf24 COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM166A FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503
Entrez ID		410	5626
HPRD ID		09617	03325
Ensembl ID		ENSG00000100299	ENSG00000175325
Uniprot IDs		A0A0C4DFZ2 B4DVI5 P15289	A0A0G2JQ02 O75360
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
Enriched GO Terms of Interacting Partners?
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