ARSA and CCDC22

Data Source:
BioGRID (two hybrid)

		ARSA	CCDC22
Description		arylsulfatase A	coiled-coil domain containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cellular_component Nucleoplasm Endosome Cytosol
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity	Protein Binding Cullin Family Protein Binding
	Biological Process	Glycosphingolipid Metabolic Process Neutrophil Degranulation	Cellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Cytoplasmic Sequestering Of NF-kappaB Protein Transport Protein Ubiquitination Endocytic Recycling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Post-translational Protein Modification Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Glycosphingolipid metabolism The activation of arylsulfatases Neutrophil degranulation	Neddylation
Drugs		4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		Metachromatic leukodystrophy (MLD)
GWAS		Blood metabolite levels ( 24816252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)	Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX	8 interacting genes: ACTG1 ARSA BLOC1S6 CPNE1 CPNE4 KRT27 OIP5 USHBP1
Entrez ID		410	28952
HPRD ID		09617	06594
Ensembl ID		ENSG00000100299	ENSG00000101997
Uniprot IDs		A0A0C4DFZ2 B4DVI5 P15289	A0A024QZ03 O60826
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
Enriched GO Terms of Interacting Partners?
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