KRT5 and SORD

Data Source:
BioGRID (proximity labelling technology)

		KRT5	SORD
Description		keratin 5	sorbitol dehydrogenase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Extracellular Space Cytosol Membrane Motile Cilium Mitochondrial Membrane Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	(R,R)-butanediol Dehydrogenase Activity L-iditol 2-dehydrogenase Activity Zinc Ion Binding Carbohydrate Binding Identical Protein Binding D-xylulose Reductase Activity Ribitol 2-dehydrogenase Activity NAD Binding
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Glucose Metabolic Process Sorbitol Catabolic Process Response To Osmotic Stress Response To Hormone Glucuronate Catabolic Process To Xylulose 5-phosphate Flagellated Sperm Motility Response To Nutrient Levels Response To Drug Fructose Biosynthetic Process Response To Cadmium Ion Response To Copper Ion L-xylitol Catabolic Process L-xylitol Metabolic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Fructose biosynthesis Formation of xylulose-5-phosphate
Drugs		Zinc Zinc acetate	NADH Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Alzheimer's disease in APOE e4+ carriers ( 25778476)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	2 interacting genes: RELA SHBG
Entrez ID		3852	6652
HPRD ID		01010	01679
Ensembl ID		ENSG00000186081	ENSG00000140263
Uniprot IDs		P13647	Q00796
PDB IDs		3TNU 6JFV	1PL6 1PL7 1PL8
Enriched GO Terms of Interacting Partners?
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